In addition, the release of all three catecholamines-dopamine, norepinephrine and epinephrine-was significantly elevated. The effect of prolactin was dose-dependent such that the magnitude of the response increased and the response time shortened with increasing concentrations of prolactin. ![]() Ovine prolactin at 8 to 200 micrograms/ml significantly stimulated the release of total catecholamines after 12 h of incubation. Catecholamine release into the medium were measured at 3, 6, 12 and 24 h. Following preincubation, the cells were treated with ovine prolactin or angiotensin II at 8, 40 and 200 micrograms/ml or cortisol at 10(-8), 10(-7) and 10(-6)M for 24 h. ![]() Adrenal medulla from fetal, newborn and adult pregnant sheep was collected, dispersed into single cells and plated. The present study was undertaken to investigate the direct effects of the hormones prolactin, angiotensin II and cortisol on catecholamine release from fetal adrenal medulla, and to determine whether the effect of the hormones change during development into adulthood. Little is known regarding the endocrine regulation of adrenal medullary catecholamine secretion in the fetus. ![]() ![]() In the ovine fetus, the adrenal medulla activity secretes catecholamines into the circulation under normal and stress conditions.
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